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Users on Reddit have reported experiences that align with skin hypersensitivity, and related sensory disturbances while on GLP-1 medications, although terms like "allodynia" or "sunburn skin pain" are not frequently used explicitly. These sensations are often described by users who also have pre-existing conditions like fibromyalgia, where GLP-1s sometimes appear to exacerbate their symptoms.

Experiences with Skin Hypersensitivity and Related Pain:

Some users with fibromyalgia describe intense sensory experiences. One user stated, "The chills…. Mixed with fibro temp intolerance, is just insane. Feels like I’m getting dunked in an ice bath while flickered by a flame torch. "[1] This suggests a heightened, painful response to temperature.

Another user with Fibromyalgia and CFS/ME reported, "When I first started on Mounjaro for my T2, I had horrible anxiety, fatigue, skin tingling, and even worse temperature dysregulation. "[2]

A medical professional on Reddit mentioned seeing "A painful sensory neuropathy, possibly small-fiber or mixed" as a severe side effect of GLP-1s. [3]

Users with fibromyalgia also report a general worsening of their condition. One said, "I swear my fibro pain (dull and achy) was worse on those meds, especially Ozempic. "[4] Another noted, "yes it made my fibro pain and fatigue worse! "[5]

Intense cold sensations and shivers are also reported. One user described, "And I get what I refer to as \"the shivers. \" I get so cold that I shiver and I have to get into bed, fully clothed, under the comforter. "[6]

Remedies and Preventions Recommended:

Time and Adaptation: For the user experiencing "skin tingling" and temperature dysregulation, they noted, "My body adapted after maybe 6 weeks? "[2]

Managing Chills and Temperature Sensitivity:

One user recommended, "For the chills, I used a heated blanket and sometimes took a Tylenol. "[4]

Another found relief from magnified chills with "long showers. "[7]

For severe shivers, getting into bed fully clothed under a comforter was a coping mechanism. [6]

Dosage Adjustment:

A user with fibromyalgia who experienced magnified fibro pain stated, "My body can’t handle more than 20, even though I have tried multiple times to acclimate from . 10 to . 25, I just can’t handle the side effects of fibro pain past . 20. I still achieve the weight loss, however it’s a slower process because I’m not taking the higher dosage. "[7]

Another user with fibromyalgia and POTS experiencing autonomic issues suggested, "My recommendations are to go down on the GLP-1. "[8]

Discontinuation for Hypersensitivity: Prescribing information for Wegovy (a semaglutide) includes a warning: "Hypersensitivity Reactions: Anaphylactic reactions and angioedema have been reported postmarketing. Discontinue WEGOVY if suspected and promptly seek medical advice (5. 6). "[9] While this is a general warning, it is relevant for severe hypersensitivity responses.